Neumatocele traumático: una presentación inusual del trauma cerrado de tórax en paciente de 21 años / Traumatic pneumatocele: an unusual presentation of blunt chest trauma in a 21-year-old patient

El neumatocele traumático, o pseudoquiste pulmonar traumático, es una complicación infrecuente del trauma cerrado de tórax, caracterizada por lesiones cavitadas únicas o múltiples de paredes fibrosas bien delimitadas, sin revestimiento epitelial. Representa un reto diagnóstico ante la prevalencia de etiologías más frecuentes de cavitación pulmonar, presentación clínica inespecífica y el carácter subreportado de la patología. Se presenta el caso de un paciente de 21 años, con cuadro clínico de fiebre y dolor torácico posterior a traumatismo contuso por accidente en motocicleta, con identificación de una lesión cavitada rodeada de vidrio esmerilado, ubicada en lóbulo superior derecho en tomografía de tórax. Se ofreció tratamiento antibiótico ante la sospecha clínica de sobreinfección. Sin embargo, se atribuyó la alteración pseudoquística pulmonar al antecedente traumático. En ocasiones las cavitaciones pulmonares postrauma no son identificadas en la atención inicial, por ende, es fundamental la evaluación clínica e imagenológica subsecuente.

Traumatic pneumatocele, or traumatic pulmonary pseudocyst, is a rare complication of blunt chest trauma, characterized by multiple or unique cavitary lesions, with well-defined fibrous walls without epithelial lining. It represents a diagnostic challenge due to the higher prevalence of other etiologies of lung cavities, nonspecific clinical features and the under-reported nature of this pathology. We present the case of a 21-year-old male with fever and chest pain after a blunt chest trauma in a motorcycle accident, with identification of a cavity in the right upper lobe, surrounded by ground glass opacities. Antibiotic therapy was administered after clinical suspicion of superinfection, however, the cavitary lesion was attributed to the trauma. Occasionally, traumatic pulmonary pseudocysts are not identified during initial assessment, therefore, clinical and imagenologic follow-up is essential.

Traumatismo torácico por arma blanca / Thoracic trauma by a bladed weapon

Resumen Objetivos Describir las características, índices de gravedad de traumatismo (IGT), morbilidad, mortalidad y factores asociados a mortalidad en pacientes hospitalizados por traumatismo torácico por arma blanca (TTAB). Materiales y Método Estudio analítico transversal. Período enero de 1981 a diciembre de 2017. Revisión base de datos prospectiva, protocolos quirúrgicos, fichas clínicas. Se describe y compara las características de los TTAB. Se calculó IGT: Injury Severity Score (ISS), Revised Trauma Score ( RTS-T) y Trauma Injury Severity Score (TRISS). Resultados Total 4.163 pacientes hospitalizados por TT, 2.286 hospitalizados por TTAB. Hombres: 2.131 (93,2%), edad promedio 27,8 ± 10,7 años, TTAB aislado 2.035 (89,0%), asociado a lesiones extratorácicas 251 (11,0%) y de éstos 124 (5,5%) se consideraron politraumatismos. Mecanismos principales del traumatismo: agresión 2.246 (98,3%) y autoagresión 22 (1,0%). Lesiones y hallazgos torácicos más frecuentes: neumotórax 1.473 (64,4%), hemotórax 1.408 (61,6%), enfisema subcutáneo 485 (21,2%). Tratamiento definitivo: pleurotomía 1.378 (60,3%), cirugía torácica 537 (23,5%) y tratamiento médico 370 (16,2%). Hospitalización promedio 6,2 ± 6,5 días, IGT: ISS promedio 10,9 ± 7,2, RTS-T promedio 11,6 ± 1,4 y TRISS promedio 3,6. Morbilidad: 318 (13,9%). Mortalidad: 32 (1,4%). Conclusión Los TTAB ocurren frecuentemente en hombres jóvenes por agresión. La mayoría se puede tratar con pleurotomía exclusiva.

Aim Our objectives are to describe and correlate the clinical characteristics, trauma severity indexes (TSI) and morbidity and mortality in patients hospitalized for thoracic trauma by a bladed weapon (TTBW). Materials and Method Transversal analytic study. Period January-1981 to December-2017. Prospective database review, surgical protocols, clinical files. The characteristics of the TTBW are described and compared. Injury Severity Score (ISS), Revised Trauma Score (RTS-T) and Trauma Injury Severity Score (TRISS) were calculated. Results Total of 4,163 patients hospitalized for TT, 2,286 hospitalized for TTBW. Men: 2,131 (93.2%), average age 27.8 ± 10.7 years, isolated TTBW 2,035 (89.0%), associated with extra thoracic injuries 251 (11.0%) and of these 124 (5.5%) were considered polytrauma. Main mechanisms of trauma: Aggression 2,246 (98.3%) and self-aggression 22 (1.0%). Most frequent injuries and thoracic findings: pneumothorax 1,473 (64.4%), hemothorax 1,408 (61.6%), subcutaneous emphysema 485 (21.2%). Definitive treatment: Pleurotomy 1,378 (60.3%), thoracic surgery 537 (23.5%) and medical treatment 370 (16.2%). Average hospital stay: 6.2 ± 6.5 days. ISS average 10.9 ± 7.2, RTS-T average 11.6 ± 1.4 and TRISS average 3.6. Morbidity: 318 (13.9%). Mortality: 32 (1.4%). Discussion TTBW are frequent in our environment, unlike on an international level. Conclusions TTBW frequently occur in young male patients due to aggression. The majority can be treated with exclusive pleurotomy.

Avulsión de bronquio fuente derecho debido a traumatismo torácico cerrado / Right main bronchus avulsion due to thoracic blunt trauma

La incidencia de roturas traqueobronquiales secundarias a un traumatismo torácico cerrado es baja, y la mayoría de estos pacientes no llegan con vida a los centros de atención hospitalaria. La presentación clínica es variable dependiendo de la localización de las lesiones, los daños asociados y si las estructuras peribronquiales permanecen íntegras. Para su diagnóstico temprano se debe tener un alto índice de sospecha clínica y una correcta interpretación de los hallazgos semiológicos y radiológicos, lo que permite su rápida y correcta resolución. La demora en el tratamiento aumenta tanto la mortalidad como las complicaciones tempranas y tardías.

The incidence of tracheobronchial ruptures secondary to blunt thoracic trauma is low and most affected patients do not arrive alive to hospitals. Clinical presentation varies with the location of lesions, associated injuries and whether the peribronchial structures remain intact. Early diagnosis requires a high index of clinical suspicion and a correct interpretation of semiologic and radiologic findings, which allows for a rapid and correct resolution. Delay in treatment increases the mortality as well as early and late complications.

Hernia diafragmática secundaria a trauma: presentación tardía / Complicated diaphragmatic hernia: late outcome of trauma

Resumen Introducción: La hernia diafragmática complicada de presentación tardía constituye una urgencia quirúrgica. Los objetivos del presente estudio son la descripción de las características del diagnóstico de las hernias diafragmáticas de presentación tardía, tratamiento, resultados y la identificación del punto de corte entre el inicio de los síntomas y el desarrollo de necrosis. Pacientes y Métodos: Estudio retrospectivo de una serie de casos constituida por todos los pacientes operados por hernia diafragmática complicada de presentación tardía entre los años 2006 y 2016. Se midieron variables categóricas y continuas que se presentan con estadística descriptiva. Se utilizaron curvas Receiver Operating Characteristics (ROC) a las 6 y 12 h desde el inicio de los síntomas, para determinar el punto de corte del tiempo de presentación clínica en pacientes sometidos a resección de algún órgano. Una vez establecido el punto de corte se calcularon la sensibilidad; especificidad; las razones de verosimilitud positiva y negativa; los valores predictivos positivo y negativo; y la prevalencia. Resultados: La presentación clínica, estudio, diagnóstico y tratamiento fue similar a lo descrito en la literatura quirúrgica. Se estableció el punto de corte a las 12 h con sensibilidad de 80% y especificidad de 83%. Conclusiones: El diagnóstico y tratamiento de estos pacientes debería ser llevado a cabo antes de las 6 h desde el inicio de los síntomas. Aun cuando el universo descrito es reducido, se sugiere que después de las 12 h desde el momento de la estrangulación, los órganos comprometidos se encontrarán necróticos requiriendo resección quirúrgica.

Introduction: Late presentation of traumatic diaphragmatic hernia constitutes a true surgical emergency. The purposes of this study were to describe the diagnostic characteristics, treatment and outcomes of late presentation diaphragmatic hernias and to identify a cutoff point from the onset of symptoms to necrosis development. Patients and Methods: A retrospective series of cases constituted by all patients subjected to emergency diaphragmatic hernia repair form 2006 to 2016 was studied. Categorical and continuous variables were measured and analyzed with descriptive statistics. Receiver Operating Characteristics (ROC) curves at 6 and 12 hours from the onset of symptoms were used to determine the cutoff point for organ resection. Once stablished the cutoff point, sensitivity, specificity, positive and negative predictive values and prevalence were calculated. Results: Clinical presentation, diagnostic study and surgical treatment were similar to what has been already described. The cutoff point was defined at 12 hours from the onset of symptoms with 80% sensitivity and 83% sensibility. Conclusions: The diagnosis and treatment of these cases should be carried on before the first 6 hours after the onset of symptoms. Even though the universe of this study was small, we may suggest that after 12 hours form the onset of symptoms, the implicated organs would be found necrotic requiring surgical resection.

Rotura traqueal completa asociada a lesión del conducto torácico posterior a trauma torácico cerrado: reporte de un caso / Full tracheal rupture associated with posterior thoracic duct injury to blunt chest trauma: a case report

Antecedentes: La rotura traqueal completa y la lesión de conducto torácico representan complicaciones raras del trauma torácico cerrado. Método: Se presenta el caso de un paciente con rotura completa de la tráquea asociada a rotura del conducto torácico que fue operado en el Hospital del Trabajador. Discusión y conclusiones: La identificación y el manejo oportuno de estas lesiones disminuyen la morbimortalidad asociada a trauma.

Background: Tracheal rupture and thoracic duct lesion are rare complications of blunt thoracic trauma. Method: We present in this article the case of a patient with complete tracheal rupture and thoracic duct lesion treated in Hospital del Trabajador. Discussion and conclusions: Early identification and prompt management of this conditions reduce morbimortality associated with trauma.

Tracheobronchial injuries in chest trauma: a 17-year experience / Lesões traqueobrônquicas no trauma torácico: experiência de 17 anos

ABSTRACT Objective: to discuss the clinical and therapeutic aspects of tracheobronchial lesions in victims of thoracic trauma. Methods: we analyzed the medical records of patients with tracheobronchial lesions treated at the São Paulo Holy Home from April 1991 to June 2008. We established patients' severity through physiological (RTS) and anatomical trauma indices (ISS, PTTI). We used TRISS (Trauma Revised Injury Severity Score) to evaluate the probability of survival. Results: nine patients had tracheobronchial lesions, all males, aged between 17 and 38 years. The mean values ​​of the trauma indices were: RTS - 6.8; ISS - 38; PTTI - 20.0; and TRISS - 0.78. Regarding the clinical picture, six patients displayed only emphysema of the thoracic wall or the mediastinum and three presented with hemodynamic or respiratory instability. The time interval from patient admission to diagnosis ranged from one hour to three days. Cervicotomy was performed in two patients and thoracotomy, in seven (77.7%), being bilateral in one case. Length of hospitalization ranged from nine to 60 days, mean of 21. Complications appeared in four patients (44%) and mortality was nil. Conclusion: tracheobronchial tree trauma is rare, it can evolve with few symptoms, which makes immediate diagnosis difficult, and presents a high rate of complications, although with low mortality.

RESUMO Objetivo: discutir os aspectos clínicos e terapêuticos de lesões traqueobrônquicas em vítimas de trauma torácico. Métodos: análise de dados dos prontuários de pacientes com lesões traqueobrônquicas atendidas na Santa Casa de São Paulo no período de abril de 1991 a junho de 2008. A caracterização da gravidade dos doentes foi feita por meio de índices de trauma fisiológico (RTS) e anatômicos (ISS, PTTI). O TRISS (Trauma Revised Injury Severity Score) foi utilizado para avaliar a probabilidade de sobrevida. Resultados: nove doentes tinham lesões traqueobrônquicas, todos do sexo masculino, com idades entre 17 e 38 anos. Os valores médios dos índices de trauma foram: RTS- 6,8; ISS- 38; PTTI-20,0; TRISS-0,78. Com relação ao quadro clínico, seis apresentaram apenas enfisema de parede torácica ou do mediastino e três doentes se apresentaram com instabilidade hemodinâmica ou respiratória. O intervalo de tempo necessário para se firmar o diagnóstico, desde a admissão do doente, variou de uma hora a três dias. Cervicotomia foi realizada em dois pacientes e toracotomia foi realizada em sete (77,7%), sendo bilateral em um caso. O tempo de internação variou de nove a 60 dias, média de 21 dias. Complicações apareceram em quatro pacientes (44%) e a mortalidade foi nula. Conclusão: o trauma da árvore traqueobrônquica é raro, pode evoluir com poucos sintomas, o que dificulta o diagnóstico imediato, e apresenta alto índice de complicações embora com baixa mortalidade.

Upper thoracic spine fracture associated with fracture of the sternum / Fratura da parte superior da coluna torácica associada à fratura do esterno / Fractura de columna torácica alta asociada a fractura del esternón

ABSTRACT Objectives: The objectives of this presentation are to analyze the kinematics that causes this association, describe the impact of the injury, and evaluate the treatment performed Methods: Three cases are analyzed by quantifying the displacement and angulation of the sternum, the characteristics of the spinal injury and deformity, treatment, and complications Results: The mechanism that causes the injury is flexion-distraction, the component of the vertebral body presented is type A, and the most affected region was T5. Two patients had neurological picture E. Sternum injury was caused by direct trauma Conclusion: The association of these was observed in patients who have suffered from high-energy trauma in a car accident. There was no relationship between the angulation of the sternum and its displacement to the degree of kyphosis and displacement of the thoracic spine. It is important to carry out good radiographic studies that include the sternum when there is suspicion of this relationship.

RESUMO Objetivos: Os objetivos desta apresentação são analisar a cinemática que causa essa associação, descrever o impacto da lesão e avaliar o tratamento realizado. Métodos:: São analisados três casos, quantificando o deslocamento e a angulação do esterno e as características da lesão na coluna vertebral e deformidade, o tratamento e as complicações. Resultados: O mecanismo que provoca a lesão é a flexão-distração, o componente do corpo vertebral apresentado é de tipo A e a região mais afetada foi T5. Dois pacientes tinham quadro neurológico E. A lesão esterno foi causada por trauma direto. Conclusão: A associação destes foi observada em pacientes que sofreram trauma de alta energia em acidente automobilístico. Não encontramos relação entre a angulação do esterno e seu deslocamento com o grau de cifose ou deslocamento da coluna torácica. É importante realizar bons estudos radiográficos que incluam o esterno quando houver suspeita dessa relação.

RESUMEN Objetivos: Los objetivos de esta presentación son analizar la cinemática que ocasiona esta asociación, describir la repercusión de la lesión y evaluar el tratamiento realizado. Métodos: Se analizan tres casos, cuantificando desplazamiento y angulación del esternón y las características de la lesión vertebral y deformidad, el tratamiento y las complicaciones. Resultados:: El mecanismo que provoca la lesión es flexo-distracción, el componente del cuerpo vertebral presentado es de tipo A y la región más afectada fue T5. Dos pacientes tenían cuadro neurológico E. La lesión del esternón se debió a trauma directo. Conclusión: La asociación de estas se vio en pacientes que habían sufrido trauma de alta energía durante un accidente automovilístico. No encontramos relación entre la angulación del esternón y su desplazamiento con el grado de cifosis o desplazamiento en la columna torácica. Es importante realizar buenos estudios radiográficos que incluyan el esternón al sospechar esta relación.

Caracterización de lesionados con hemoneumotórax traumático en el Hospital Universitario "General Calixto García" (2012 - 2014) / Characterization of injured patients with traumatic hemo-pneumothorax at General Calixto García University Hospital (2012-2014)

Introducción: el trauma torácico constituye una causa frecuente de mortalidad temprana y tardía que ocurre en 25 por ciento del total de lesionados. Objetivo: caracterizar el comportamiento clínico-epidemiológico de los lesionados con diagnóstico de hemoneumotórax traumático. Métodos: se realizó un estudio observacional descriptivo, longitudinal retrospectivo, que incluyó 357 lesionados con diagnóstico de hemoneumotórax traumático, ingresados en el servicio de cirugía general del Hospital Universitario General Calixto García desde el 1 de enero de 2012 hasta 31 de diciembre de 2014. Se incluyeron variables como: edad, sexo, causa del trauma, atención médica prehospitalaria y hospitalaria, índice de gravedad de la lesión, lesiones asociadas, estadía hospitalaria y estado al egreso. Resultados: predominó el sexo masculino (78,1 por ciento ) y la edad de 20 a 39 años (26,0 por ciento ). Los accidentes de tránsito fueron la principal causa del trauma y la gravedad se incrementó por la presencia de traumas raquimedulares y choque hipovolémico. Los lesionados clasificados como moderados según el índice de gravedad de la lesión fueron 53,3 por ciento. Los lesionados que llegaron al hospital una a dos horas de ocurrido el trauma fueron 41,2 por ciento. La estadía hospitalaria con mayor número de egresados vivos fue entre cuatro y cinco días. Los fallecimientos ocurrieron en su mayoría después de los siete días. Las lesiones asociadas y la descompensación de las enfermedades crónicas fueron las responsables del mayor número de fallecidos (n= 46 12,9 por ciento). Conclusiones: las características clínico-epidemiológicas de los lesionados con hemoneumotórax traumático coinciden con las reportadas por estudios nacionales e internacionales(AU)

Introduction: thoracic trauma is a common cause for early and late mortality, occurring in 25 percent of all injured patients. Objective: to characterize the clinical and epidemiological behavior of the injured patients with traumatic hemo-pneumothorax. Methods: a descriptive, retrospective, longitudinal study was carried out, involving 357 injured patients diagnosed with traumatic hemo-pneumothorax and admitted to the general surgery service at General Calixto García University Hospital from January 1, 2012 until December 31, 2014. The variables included were age, sex, cause for trauma, pre-hospital and hospital care, severity rate of injury, associated injuries, hospital stay and discharge status. Results: there was a predominance of males (78.1 percent ) and of ages 20-39 years (26.0 percent ). Traffic accidents were the main cause for trauma and severity increased by the presence of hypovolemic shock trauma and spinal cord injuries. According to the injury severity index, 53.3 percent of the injured patients were classified as moderate. 41.2 percent of the injured patients arrived at the hospital 1-2 hours after the trauma. The hospital stays for highest number of admitted alive was between four and five days. The deaths occurred mostly after seven days. Associated injuries and decompensation of chronic diseases were causes for the largest amount of deaths (12.9 percent , n= 46). Conclusions: the clinical and epidemiological characteristics of the injured patients with traumatic hemo-pneumothorax match those reported by national and international studies(AU)

Associated factors to empyema in post-traumatic hemotorax / Fatores associados ao empiema em pacientes com hemotórax retido pós-traumático

ABSTRACTObjective:to analyze the associated factors with empyema in patients with post-traumatic retained hemothorax.Methods:prospective observational study. Data were collected in patients undergoing PD during emergency duty. Variables analyzed were age, sex, mechanism of injury, side of the chest injury, intrathoracic complications of RH, laparotomy, specific injuries, rib fractures, trauma scores, days to diagnosis, diagnostic method of RH, primary indication of PD, initial volume drained, length of the first tube removal, surgical procedure. Cumulative incidence of empyema, pneumonia and pulmonary contusion and the proportion of patients with empyema or without empyema in each category of each variable analyzed were obtained.Results: the cumulative incidence of PD among trauma patients was 1.83% and the RH among those with PD was 10.63%. There were 20 cases of empyema (32.8%). Most were male in the age from 20 to 29, victims of injury by firearm on the left side of the thorax. The incidence of empyema in patients with injury by firearms was lower compared to those with stab wound or blunt trauma; higher among those with drained volume between 300 and 599 ml. The median hospital lenght of stay was higher among those with empyema.Conclusion:the incidence of PD was 1.83% and RH was 10.63%, these results are consistent with the low severity of the patients involved in this study and consistent with the literature. The incidence of empyema proved to be negatively associated with the occurrence of injury by firearms and positively associated with a drained volume between 300 and 599 ml, compared with lower or higher volumes.

RESUMOObjetivo:analisar os fatores associados ao empiema em pacientes com hemotórax retido pós-traumático.Métodos:estudo prospectivo observacional. Os dados foram coletados de pacientes submetidos à drenagem pleural de emergência. Foram analisadas: idade, sexo, mecanismo de trauma, lado da lesão torácica, complicações intratorácicas decorrentes do hemotórax retido, laparotomia, lesões específicas, fratura de arcos costais, índices de trauma, dias até o diagnóstico, método diagnóstico do HR, indicação primária da drenagem pleural, volume inicial drenado, dias de permanência do primeiro dreno, procedimento cirúrgico. Obteve-se a incidencia acumulada de empiema, pneumonia e contusão pulmonar e a incidência de empiema em cada categoria das variaìveis analisadas.Resultados:a incidência acumulada de drenagem pleural por trauma foi 1,83% e a de hemotórax retido entre aqueles com derrame pleural foi de 10,63%. Houve 20 casos de empiema (32,8%). A maioria tinha entre 20 e 29 anos, era do sexo masculino e sofreu ferimento por arma de fogo. A incidência de empiema entre pacientes com ferimento por arma de fogo foi inferior aos demais mecanismos; superior entre aqueles com volume drenado entre 300 e 599 ml. O tempo mediano de permanência hospitalar foi maior nos pacientes com empiema.Conclusão:as incidências de derrame pleural e hemotórax retido entre aqueles com DP nessa amostra de baixa gravidade dos pacientes foram, respectivamente, 1,83% e 10,63%. A incidência de empiema revelou-se negativamente associada à ocorrência de ferimento por arma de fogo e positivamente associada a volume drenado entre 300 e 599 ml, bem como, ao tempo mediano de permanência hospitalar.

Traumatic Diaphragmatic Hernia.

Blunt traumatic diaphragmatic ruptures are uncommon yet associated with high mortality. They occur due to blunt or penetrating thoraco-abdominal injury. Diagnosis is often missed, and a high index of suspicion is vital. They may present acutely or delayed as respiratory distress or obstruction. They can be managed through a laparotomy or a thoracotomy and in the present day with minimal access surgery. We report an interesting case of blunt traumatic diaphragmatic hernia in a 48-year-old man presenting after abdomino-thoracic injury due to fall from height. He had herniation of the colon and stomach. Through a left subcostal incision, the herniated organs were reduced, and the diaphragmatic defect closed with prolene suture.

Role of microRNAs 221/222 on Statin Induced Nitric Oxide Release in Human Endothelial Cells / Papel dos microRNAs 221/222 na Liberação de Óxido Nítrico Induzida por Estatinas em Células Endoteliais Humanas

Background: Nitric oxide (NO) has been largely associated with cardiovascular protection through improvement of endothelial function. Recently, new evidence about modulation of NO release by microRNAs (miRs) has been reported, which could be involved with statin-dependent pleiotropic effects, including anti-inflammatory properties related to vascular endothelium function. Objective: To evaluate the effects of cholesterol-lowering drugs including the inhibitors of cholesterol synthesis, atorvastatin and simvastatin, and the inhibitor of cholesterol absorption ezetimibe on NO release, NOS3 mRNA expression and miRs potentially involved in NO bioavailability. Methods: Human umbilical vein endothelial cells (HUVEC) were exposed to atorvastatin, simvastatin or ezetimibe (0 to 5.0 μM). Cells were submitted to total RNA extraction and relative quantification of NOS3 mRNA and miRs -221, -222 and -1303 by qPCR. NO release was measured in supernatants by ozone-chemiluminescence. Results: Both statins increased NO levels and NOS3 mRNA expression but no influence was observed for ezetimibe treatment. Atorvastatin, simvastatin and ezetimibe down-regulated the expression of miR-221, whereas miR-222 was reduced only after the atorvastatin treatment. The magnitude of the reduction of miR-221 and miR-222 after treatment with statins correlated with the increment in NOS3 mRNA levels. No influence was observed on the miR-1303 expression after treatments. Conclusion: NO release in endothelial cells is increased by statins but not by the inhibitor of cholesterol absorption, ezetimibe. Our results provide new evidence about the participation of regulatory miRs 221/222 on NO release induction mediated by statins. Although ezetimibe did not modulate NO levels, the down-regulation of miR-221 could involve potential effects on endothelial function. .

Fundamento: O óxido nítrico (NO) tem sido amplamente associado com proteção cardiovascular através de melhoria da função endotelial. Recentemente, novas evidências sobre a modulação do NO na liberação de microRNAs (miRs) têm sido relatadas, o que poderia estar envolvido com efeitos pleiotrópicos dependentes de estatinas, incluindo propriedades anti-inflamatórias relacionadas com a função do endotélio vascular. Objetivo: Avaliar os efeitos dos medicamentos redutores de colesterol, incluindo os inibidores da síntese de colesterol, atorvastatina e sinvastatina, e o inibidor da absorção de colesterol, ezetimiba, na liberação de NO, expressão do mRNA do NOS3 e miRs potencialmente envolvidos na biodisponibilidade do NO. Métodos: Células endoteliais da veia umbilical humana (HUVEC) foram expostas à atorvastatina, sinvastatina ou ezetimiba (0 a 5,0 μM). As células foram submetidas à extração do RNA total e quantificação relativa de mRNA do NOS3 e dos miRs-221,-222 e -1303 por qPCR. A liberação de NO foi medida em sobrenadantes por ozônio-quimioluminescência. Resultados: Ambas as estatinas aumentaram os níveis de NO e a expressão do mRNA do NOS3, mas nenhum efeito foi observado em relação ao tratamento com ezetimiba. A atorvastatina, sinvastatina e ezetimiba regularam negativamente a expressão do miR-221, enquanto que o miR-222 reduziu somente após o tratamento com atorvastatina. A magnitude da redução de miR-221 e miR-222 após tratamento com estatinas correlacionou com o incremento nos níveis de mRNA do NOS3. Nenhuma influência foi observada sobre a expressão do miR-1303 após os tratamentos. Conclusão: A liberação de NO pelas células endoteliais é aumentada por estatinas, mas não pelo inibidor da absorção de colesterol ezetimiba. Nossos resultados fornecem novas evidências sobre a participação dos miRs regulatórios 221/222 na liberação de NO mediada por estatinas. Embora a ezetimiba não tenha modulado os níveis de NO, a regulação negativa ...

A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats

Cardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg−1·day−1), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-α) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-α levels were elevated after contusion (P=0.001 and P=0.001). Seven days later, Tn-I and TNF-α levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P=0.001 and P=0.011, respectively). Histopathological degeneration and necrosis scores were statistically lower in the methylprednisolone and quercetin combination group compared to the group treated only with methylprednisolone (P=0.017 and P=0.007, respectively). However, only degeneration scores were lower in the combination therapy group compared to the group treated only with quercetin (P=0.017). Inducible nitric oxide synthase positivity scores were decreased in all treatment groups compared to the untreated groups (P=0.097, P=0.026, and P=0.004, respectively). We conclude that a combination of quercetin and methylprednisolone can be used for the specific treatment of cardiac contusion.

Thoracoscopic and endovascular management of retained haemothoarx associated with an intercostal artery pseudoaneurysm.

Intercostal artery pseudoaneurysm (IAP) is a rare entity and may complicate a percutaneous intervention through an intercostal space or follow thoracic trauma. Its rupture into the pleural space can give rise to haemothorax, which if untreated may lead to a retained haemothorax (RH). Traditionally both the IAP and the RH are managed by a thoracotomy. We report a patient who developed an IAP with haemothorax following a trauma. The diagnosis was established by computed tomography. The patient was treated by endovascular embolisation of the IAP followed by thoracoscopic decortications of the RH.

Spontaneous Obliteration of Right Ventricular Pseudoaneurysm after Blunt Chest Trauma: Diagnosis and Follow-Up with Multidetector CT

Right ventricular (RV) pseudoaneurysm caused by trauma is very rare. We report a case of RV pseudoaneurysm which resolved without surgical treatment in a patient who survived a falling accident. Echocardiography failed to identify the pseudoaneurysm. Electrocardiography-gated CT showed a 17-mm-sized saccular pseusoaneurysm arsing from the RV outflow tract with a narrow neck. Follow-up CT after two months showed spontaneous obliteration of the lesion.

Abordaje laparoscópico de hernia paraesofágica asistido por robot reporte de un caso / Laparoscopic approach to robot-assisted paraesophageal hernia report of a case

Paciente femenino de 55 años con antecedente de trauma torácico izquierdo con disfagia, disnea, dolor retroesternal y epigástrico, la serie contrastada de esófago estomago duodeno muestra la presencia de hernia paraesofágica que igualmente se corrobora en endoscopia digestiva superior y los estudios tomográficos se plantea la necesidad de la resolución quirúrgica y para ello se realiza abordaje laparoscópico asistido por sistema da Vinci®, se evidencia elongación de pilares del hiato esofágico y desplazamiento a través del fundus gástrico cubierto por peritoneo hacia el tórax izquierdo, se realiza, liberación de los elementos del saco herniario y posterior escisión del mismo, cierre del defecto y reforzado con una banda de politetrafluoroetileno expandido de 5 x 8 cm. Después de la cirugía la paciente se recupera satisfactoriamente inicia dieta a las 24 horas de postoperatorio, la estancia hospitalaria es de 3 días. El abordaje laparoscópico se presenta como una opción que ofrece mayores beneficios al paciente en comparación con el abordaje abierto. Informes sobre corrección de hernia paraesofágica asistida por sistema Da Vinci son limitados y serán tratados en este informe de caso(AU)

Female patient 55 years female with a history of left thoracic trauma with dysphagia, dyspnea, retrosternal and epigastric pain, esophageal contrasted series esophagus stomach duodenum shows the presence of paraesophageal hernia which is also corroborated by upper endoscopy and CT scans raises the need for surgical resolution and it is performed laparoscopic-assisted da Vinci robotic mark, elongation evidenced esophageal hiatus pillars and scrolling through the gastric fundus covered by peritoneum to the left chest, is performed, release of the elements of the sac and subsequent cleavage of the same defect closure and reinforced with a strip of expanded polytetrafluoroethylene 5 x 8 cm. following surgery the patient is recovering diet started at 24 hours after surgery, the hospital stay is 3 days. The laparoscopic approach is presented as an option that provides greater benefits to patients compared with the open approach. Reports paraesophageal hernia correction aided brand da vinci robotic system are limited and will be discussed in this case report(AU)

Hernia diafragmática postraumática: caso clínico / Traumatic diaphragmatic hernia: case report

Introducción: las hernias diafragmáticas traumáticas se producen después de un traumatismo cerrado o penetrante. El caso que se reporta en el presente trabajo constituye un diagnóstico incidental e inusual en la clínica para especialistas y personal en formación. Caso clínico: se presenta una mujer con historia de trauma toraco-abdominal por accidente de tránsito hace 30 años, con imagen radiopaca en la radiografía de tórax en la base pulmonar derecha en ocasión de afección respiratoria. La persistencia de la imagen después de tratamiento y remisión del cuadro, hizo posible el diagnóstico incidental de hernia diafragmática por tomografía axial computarizada. Discusión: un alto índice de sospecha es esencial durante la evaluación inicial del paciente con trauma toraco-abdominal contuso o penetrante. Conclusiones: las hernias diafragmáticas postraumáticas representan un desafío clínico y quirúrgico para su diagnóstico.

Introduction. Traumatic diaphragmatic hernias occur after blunt or penetrating trauma. The case reported in this article is an incidental and unusual diagnosis in clinical practice. Case. We report a woman with a history of thoraco-abdominal trauma from a road accident that occurred 30 years ago. In the chest X-ray we found a radioopacity in the right lung base resulting from a respiratory infection. The image persisted in spite of effective treatment for the underlying respiratory condition, which made us suspect a diaphragmatic hernia corroborated by computed tomography. Discussion. A high level of suspicion is essential for the initial evaluation of patients with blunt or penetrating thoraco-abdominal trauma. Conclusions. Traumatic diaphragmatic hernias constitute a clinical challenge both for diagnosis and surgical treatment.

Sternal osteomylitis due to arrow-head injury: A rare case report.

Sternal osteomyelitis secondary to penetrating trauma is an uncommon entity and only few cases have been reported. We report a case of sternal osteomyelitis in a patient with sickle-cell anaemia with a unique past history of arrow-head injury who presented with signs and symptoms of sternal infection. Imaging studies suggested osteomyelitis and the patient underwent sternal debridement, with a successful outcome.